HTR3A

Across TCGA pan-cancer cohorts, HTR3A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HTR3A data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HTR3A RNA is associated with better overall survival. In most high-consensus cancer types, elevated HTR3A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, KIRC, and CESC are the cancer types where HTR3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.784	0.629	<.001	106	view →
KIRC	OS	Median	All	0.537	0.726	<.001	78	view →
CESC	DFS	Tertile	IV	0.740	0.297	.006	66	view →
UCEC	DFS	Median	All	0.545	0.740	<.001	52	view →
LUAD	OS	Tertile	III,IV	0.381	0.598	.005	31	view →
LIHC	OS	Quartile	All	0.544	0.711	.003	27	view →
SARC	OS	Quartile	All	0.742	0.436	.001	27	view →
SCLC	OS	Median	II,III,IV	0.387	0.710	.003	24	view →
MESO	DFS	Median	IV	0.168	0.485	<.001	16	view →
SKCM	DFS	Median	All	0.314	0.165	.009	15	view →
LUSC	OS	Quartile	III,IV	0.418	0.746	.003	11	view →
PAAD	DFS	Tertile	All	0.125	0.376	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HTR3A–HNSC (OS)

Open the HNSC breakdown →