HTR3A

Across TCGA patient cohorts, HTR3A mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR3A-associated genes across cancer lineages are GAPDH, FoxM1, and Ku80. Each is linked with HTR3A in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR3A-to-partner and partner-to-HTR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by HTR3A-low versus HTR3A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3A→partner) and Y-score (partner→HTR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GAPDH →	+0.830	+2.179	.008	.035	3	3
UCEC	FoxM1 →	+0.201	+1.495	.018	.034	3	3
UCEC	Ku80 →	+0.214	+1.498	.005	.032	3	3
UCEC	ATM →	-0.474	-2.209	.001	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.488	+1.926	.012	.008	3	3
UCEC	cIAP →	+0.093	+1.916	.040	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

GAPDH by HTR3A expression — LUSC

Explore this box plot interactively →