HTR3A

Across TCGA cell cohorts, HTR3A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,400 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HTR3A-associated GO terms across cancer lineages are Serotonin-gated cation-selective signaling pathway, Cytoplasmic translation, and Regulation of myoblast fusion. Each is linked with HTR3A in more than 8 cancer types. Because this analysis shows association rather than direction, both HTR3A-to-partner and partner-to-HTR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serotonin-gated cation-selective signaling pathway grouped by HTR3A-low versus HTR3A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3A→partner) and Y-score (partner→HTR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Serotonin-gated cation-selective signaling pathway →	+1.232	+2.446	<.001	<.001	3	9
LUNG_SCLC	Cytoplasmic translation →	+0.073	+1.690	<.001	.006	3	7
BONE	Regulation of myoblast fusion →	+0.086	+0.127	<.001	.009	2	7
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.091	+1.898	<.001	.001	3	6
LUNG_NSCLC_LUAD	Nucleobase-containing compound transport →	+0.038	+0.432	.002	.009	3	5
LUNG_SCLC	Negative regulation of alpha-beta T cell differentiation →	-0.155	-1.640	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,400 associations by consensus.

Serotonin-gated cation-selective signaling pathway by HTR3A expression — LUNG_SCLC

Explore this box plot interactively →