HTR3A

Across TCGA cell cohorts, HTR3A mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HTR3A-associated genes across cancer lineages are DPRX, WFDC5, and DEFB124. Each is linked with HTR3A in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR3A-to-partner and partner-to-HTR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by HTR3A-low versus HTR3A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3A→partner) and Y-score (partner→HTR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DPRX →	+0.092	+2.813	.001	.007	3	2
LUNG_SCLC	WFDC5 →	+0.146	+4.070	.005	.003	3	1
LUNG_SCLC	DEFB124 →	+0.408	+3.898	.002	.005	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	LORICRIN →	+0.027	+3.817	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

DPRX by HTR3A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →