HTR2C

Across TCGA pan-cancer cohorts, HTR2C Mutation is linked to patient survival in 14 of 34 cancer types, making it a survival-associated HTR2C data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HTR2C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HTR2C expression acts as an unfavorable survival marker, although some lineages such as UCEC and CESC show a favorable association.

HNSC, ACC, and READ are the cancer types where HTR2C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.161	0.714	<.001	41	view →
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
READ	OS	Median	II,III,IV	0.111	0.919	<.001	27	view →
STAD	OS	Median	II,III,IV	0.243	0.671	<.001	24	view →
UCEC	OS	Median	II,III,IV	0.906	0.314	.009	20	view →
COAD	OS	Median	III,IV	0.218	0.798	<.001	16	view →
KIRC	DFS	Median	All	0.127	0.865	<.001	10	view →
PRAD	OS	Median	All	0.265	0.884	<.001	8	view →
CESC	DFS	Median	IV	1.000	0.170	.035	6	view →
BRCA	OS	Median	All	0.147	0.579	.015	6	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	6	view →
SKCM	OS	Median	II,III,IV	0.572	0.296	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

HTR2C–HNSC (OS)

Open the HNSC breakdown →