HTR1D

Across TCGA pan-cancer cohorts, HTR1D Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HTR1D data layer compared with 29 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HTR1D Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HTR1D expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

KIRP, OV, and LUSC are the cancer types where HTR1D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.141	0.904	<.001	36	view →
OV	OS	Median	II,III,IV	0.308	0.691	.033	18	view →
LUSC	DFS	Median	All	0.173	0.646	.037	12	view →
LGG	DFS	Median	All	0.110	0.826	<.001	6	view →
UCEC	DFS	Median	All	0.961	0.620	.020	6	view →
STAD	OS	Median	III,IV	0.230	0.632	.033	3	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →
BLCA	DFS	Median	III,IV	0.511	0.315	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HTR1D–KIRP (OS)

Open the KIRP breakdown →