HTR1B

Across TCGA patient cohorts, HTR1B mutation is significantly associated with the RNA expression of many other genes, with 2,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR1B-associated genes across cancer lineages are F10, GGT7, and KLRD1. Each is linked with HTR1B in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR1B-to-partner and partner-to-HTR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F10 grouped by HTR1B-low versus HTR1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1B→partner) and Y-score (partner→HTR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	F10 →	-0.556	-2.486	.007	.001	3	3
UCEC	GGT7 →	-0.658	-1.938	.001	.001	3	3
UCEC	KLRD1 →	+0.513	+2.263	<.001	<.001	3	3
CESC	PDE4DIPP8 →	+0.085	+4.669	<.001	.007	3	3
HNSC	RN7SL716P →	+0.208	+3.883	.002	.004	3	3
UCEC	FANCA →	+0.447	+2.136	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,037 associations by consensus.

F10 by HTR1B expression — UCEC

Explore this box plot interactively →