HTR1B

Across TCGA patient cohorts, HTR1B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR1B-associated genes across cancer lineages are MEK1, MSH6, and Notch1. Each is linked with HTR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1B-to-partner and partner-to-HTR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HTR1B-low versus HTR1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1B→partner) and Y-score (partner→HTR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.422	+2.584	<.001	.001	3	2
UCEC	MSH6 →	-0.333	-1.700	.003	.040	3	2
UCEC	Notch1 →	+0.176	+1.736	<.001	.007	3	2
UCEC	p90 RSK →	+0.143	+1.750	.031	.004	3	2
UCEC	Annexin-1 →	+0.676	+2.459	<.001	<.001	3	2
UCEC	Rictor_pT1135 →	-0.094	-1.874	.008	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MEK1 by HTR1B expression — UCEC

Explore this box plot interactively →