HTR1A

Across TCGA pan-cancer cohorts, HTR1A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated HTR1A data layer compared with 16 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher HTR1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HTR1A expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

THYM, OV, and SCLC are the cancer types where HTR1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
OV	OS	Median	II,III,IV	0.314	0.693	.008	30	view →
SCLC	DFS	Median	II,III,IV	0.110	0.615	<.001	24	view →
UCEC	DFS	Median	II,III,IV	1.000	0.484	.025	20	view →
BRCA	OS	Median	II,III,IV	0.650	0.913	.006	14	view →
STAD	OS	Median	All	0.341	0.672	.017	12	view →
LUSC	DFS	Median	II,III,IV	1.000	0.366	.006	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LIHC	DFS	Median	III,IV	0.077	0.414	.004	6	view →
COAD	OS	Median	IV	0.082	0.659	<.001	6	view →
LUAD	OS	Median	All	0.139	0.384	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HTR1A–THYM (OS)

Open the THYM breakdown →