HTR1A

Across TCGA pan-cancer cohorts, HTR1A RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HTR1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HTR1A RNA is repressed in tumor relative to normal tissue. In most cancer types HTR1A is over-expressed in tumor, although a few such as KIRC and PRAD show the opposite, repressed pattern.

KIRC, BRCA, and PRAD are the cancer types where HTR1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTR1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.034	.014	4	view →
BRCA	All	All	+0.026	<.001	4	view →
PRAD	All	All	−0.071	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HTR1A–KIRC

Open the KIRC breakdown →