HTR1A

Across TCGA patient cohorts, HTR1A protein abundance is significantly associated with the RNA expression of many other genes, with 2,317 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HTR1A-associated genes across cancer lineages are PRODH, SLC16A8, and SEPTIN3. Each is linked with HTR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1A-to-partner and partner-to-HTR1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HTR1A versus PRODH in GBM, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1A→partner) and Y-score (partner→HTR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.739	+0.682	.006	.001	3	1
GBM	SLC16A8 →	+0.724	+0.841	<.001	<.001	3	1
GBM	SEPTIN3 →	+0.810	+0.956	.003	<.001	3	1
GBM	RASL10A →	+0.647	+0.699	.001	<.001	3	1
GBM	NEFH →	+1.809	+1.050	<.001	<.001	3	1
GBM	RASD2 →	+0.827	+1.180	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,317 associations by consensus.

HTR1A vs PRODH — GBM

Explore this scatter interactively →