HTR1A

Across TCGA patient cohorts, HTR1A mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR1A-associated genes across cancer lineages are GAPDH, ATM, and Caspase-7-cleavedD198. Each is linked with HTR1A in more than 3 cancer types. Because this analysis shows association rather than direction, both HTR1A-to-partner and partner-to-HTR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by HTR1A-low versus HTR1A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1A→partner) and Y-score (partner→HTR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.455	+3.169	.042	.018	3	4
UCEC	ATM →	-0.784	-2.459	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.518	+2.827	.011	.001	3	3
LUAD	MAPK_pT202_Y204 →	-0.502	-3.000	.016	.036	3	2
LUAD	PDCD4 →	-0.979	-3.000	<.001	.034	3	2
LUAD	TFRC →	+1.637	+3.000	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

GAPDH by HTR1A expression — SKCM

Explore this box plot interactively →