HTR1A

Across TCGA cell cohorts, HTR1A RNA expression is significantly associated with the mutation status of many other genes, with 92 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HTR1A-associated genes across cancer lineages are SETX, PCDH10, and ADGRB2. Each is linked with HTR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1A-to-partner and partner-to-HTR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETX grouped by HTR1A-low versus HTR1A-high in URINARY_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1A→partner) and Y-score (partner→HTR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SETX →	+4.087	+0.022	.009	<.001	3	2
URINARY_TRACT	PCDH10 →	+5.087	+0.030	.004	<.001	3	2
PANCREAS	ADGRB2 →	+5.139	+0.007	<.001	<.001	3	2
PANCREAS	LAMA5 →	+2.817	+0.003	.009	<.001	3	2
PANCREAS	TPR →	+3.139	+0.004	.006	<.001	3	2
LUNG_NSCLC_LUAD	NDST3 →	+4.681	+0.010	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

SETX by HTR1A expression — URINARY_TRACT

Explore this box plot interactively →