HTR1A

Across TCGA cell cohorts, HTR1A mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HTR1A-associated genes across cancer lineages are RTP2, SPATA31E1, and OR11H1. Each is linked with HTR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR1A-to-partner and partner-to-HTR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTP2 grouped by HTR1A-low versus HTR1A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR1A→partner) and Y-score (partner→HTR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RTP2 →	+0.053	+4.786	<.001	<.001	3	2
SKIN	SPATA31E1 →	+0.028	+4.510	<.001	.001	3	1
LUNG_SCLC	OR11H1 →	+0.072	+4.044	<.001	.009	3	1
LUNG_SCLC	FAM187B →	+0.022	+4.817	.001	.001	3	1
LUNG_SCLC	DEFB105A →	+0.150	+4.643	<.001	.004	3	1
LUNG_SCLC	IFNA7 →	+0.255	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RTP2 by HTR1A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →