Across TCGA patient cohorts, HTN3 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HTN3-associated genes across cancer lineages are RPS29P26, RNA5SP198, and RN7SL607P. Each is linked with HTN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTN3-to-partner and partner-to-HTN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTN3→partner) and Y-score (partner→HTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS29P26 →	+0.348	+7.930	<.001	.008	3	2
UCEC	RNA5SP198 →	+1.922	+5.621	<.001	.004	3	2
SKCM	RN7SL607P →	+0.133	+4.034	.007	.004	3	1
SKCM	PSMA5P1 →	+0.064	+4.884	<.001	.004	3	1
SKCM	RAB28P2 →	+0.151	+5.039	<.001	.003	3	1
SKCM	OR11Q1P →	+0.643	+4.743	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

Exploration

HTN3 survival (RNA) · tumor vs normal (RNA) · all HTN3 data types