HSPH1

Across TCGA cell cohorts, HSPH1 mutation is significantly associated with the RNA expression of many other genes, with 924 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSPH1-associated genes across cancer lineages are ADRB3, OR5H8, and H4C13. Each is linked with HSPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPH1-to-partner and partner-to-HSPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRB3 grouped by HSPH1-low versus HSPH1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPH1→partner) and Y-score (partner→HSPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADRB3 →	+0.096	+3.044	.008	.008	3	1
STOMACH	OR5H8 →	+0.281	+3.209	.008	.007	3	1
STOMACH	H4C13 →	+0.417	+3.807	<.001	.002	3	1
SKIN	PNMA6F →	+0.006	+4.977	<.001	.007	3	1
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PES1 →	+0.463	+2.675	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 924 associations by consensus.

ADRB3 by HSPH1 expression — STOMACH

Explore this box plot interactively →