HSPG2

Across TCGA cell cohorts, HSPG2 mutation is significantly associated with the RNA expression of many other genes, with 1,782 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSPG2-associated genes across cancer lineages are LYG1, GPR148, and CHRNA5. Each is linked with HSPG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HSPG2-to-partner and partner-to-HSPG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by HSPG2-low versus HSPG2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPG2→partner) and Y-score (partner→HSPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.831	+2.130	<.001	<.001	3	4
BLOOD_Myeloma	GPR148 →	+0.020	+2.754	.002	.008	3	3
LUNG_SCLC	CHRNA5 →	+0.808	+3.584	.003	<.001	3	3
BLOOD_Leukemia	RFC5 →	+0.506	+3.228	.007	.004	3	3
BLOOD_Leukemia	EDA →	+0.487	+1.925	.009	.008	3	3
BLOOD_Leukemia	IQCC →	+0.606	+3.518	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,782 associations by consensus.

LYG1 by HSPG2 expression — LARGE_INTESTINE

Explore this box plot interactively →