HSPE1P4

Across TCGA pan-cancer cohorts, HSPE1P4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HSPE1P4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HSPE1P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPE1P4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and BRCA are the cancer types where HSPE1P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPE1P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.193	<.001	8	view →
BLCA	Male	All	+0.278	.002	6	view →
BRCA	All	II,III,IV	+0.161	<.001	6	view →
STAD	Male	All	+0.483	.001	5	view →
COAD	Female	II,III,IV	+0.561	.002	4	view →
LIHC	Male	All	+0.296	.001	3	view →
LUAD	All	All	+0.174	.011	3	view →
LUSC	All	All	+0.162	.005	3	view →
UCEC	All	II,III,IV	+0.474	.047	2	view →
KICH	Female	All	−0.188	.039	1	view →
KIRP	Male	All	+0.178	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HSPE1P4–HNSC

Open the HNSC breakdown →