HSPE1-MOB4

Across TCGA pan-cancer cohorts, HSPE1-MOB4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HSPE1-MOB4 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher HSPE1-MOB4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HSPE1-MOB4 expression acts as an unfavorable survival marker, although some lineages such as READ and PCPG show a favorable association.

UVM, ACC, and KIRC are the cancer types where HSPE1-MOB4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.430	0.830	<.001	126	view →
ACC	DFS	Tertile	All	0.202	0.642	<.001	66	view →
KIRC	DFS	Quartile	II,III,IV	0.577	0.827	<.001	49	view →
MESO	DFS	Quartile	III,IV	0.153	0.659	.008	45	view →
STAD	DFS	Tertile	All	0.206	0.639	.002	33	view →
BLCA	DFS	Median	All	0.454	0.559	.004	28	view →
UCEC	DFS	Median	All	0.542	0.732	.001	20	view →
READ	DFS	Tertile	All	0.929	0.638	.002	19	view →
SKCM	DFS	Tertile	IV	0.111	0.694	.004	13	view →
LIHC	OS	Quartile	III,IV	0.295	0.736	.020	13	view →
LUAD	DFS	Quartile	II,III,IV	0.626	0.841	.021	11	view →
THCA	DFS	Tertile	All	0.778	0.937	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HSPE1-MOB4–UVM (OS)

Open the UVM breakdown →