HSPB8

Across TCGA patient cohorts, HSPB8 mutation is significantly associated with the RNA expression of many other genes, with 1,101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPB8-associated genes across cancer lineages are PGAM1, PGD, and RNU6-13P. Each is linked with HSPB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPB8-to-partner and partner-to-HSPB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAM1 grouped by HSPB8-low versus HSPB8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB8→partner) and Y-score (partner→HSPB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM1 →	+0.988	+3.480	.001	.002	3	2
UCEC	PGD →	+0.642	+3.337	.005	.005	3	2
UCEC	RNU6-13P →	+0.323	+2.706	<.001	.003	3	2
UCEC	RNU6-1067P →	+0.362	+2.775	<.001	.002	3	2
SKCM	RNU6-937P →	+0.321	+2.866	<.001	.001	3	2
LUSC	MTND3P12 →	+0.063	+3.993	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,101 associations by consensus.

PGAM1 by HSPB8 expression — UCEC

Explore this box plot interactively →