HSPB8

Across TCGA pan-cancer cohorts, HSPB8 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of HSPB8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSPB8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPB8 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where HSPB8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPB8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.881	<.001	12	view →
COAD	Male	II,III,IV	−3.024	<.001	11	view →
KIRP	Male	III,IV	+2.404	<.001	11	view →
THCA	Male	III,IV	−2.532	<.001	10	view →
BLCA	Male	All	−3.697	<.001	9	view →
LUAD	Male	III,IV	−2.543	<.001	9	view →
LUSC	Female	II,III,IV	−2.998	<.001	8	view →
HNSC	Male	IV	−2.688	<.001	8	view →
STAD	Female	All	−3.325	<.001	7	view →
LIHC	All	II,III,IV	+1.874	<.001	7	view →
UCEC	All	All	−3.942	<.001	6	view →
BRCA	All	III,IV	−1.669	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

HSPB8–KIRC

Open the KIRC breakdown →