HSPB8

Across TCGA patient cohorts, HSPB8 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPB8-associated genes across cancer lineages are FoxM1, JNK_pT183_Y185, and p62 Lck ligand. Each is linked with HSPB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPB8-to-partner and partner-to-HSPB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by HSPB8-low versus HSPB8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB8→partner) and Y-score (partner→HSPB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.305	+3.169	.032	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-3.156	.031	.020	3	1
UCEC	p62 Lck ligand →	+0.470	+2.817	.008	.036	3	1
UCEC	Shc_pY317 →	-0.266	-3.169	.001	.020	3	1
UCEC	C-Raf →	+0.233	+3.000	.003	.036	3	1
UCEC	Cyclin-E2 →	+0.255	+3.009	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FoxM1 by HSPB8 expression — UCEC

Explore this box plot interactively →