HSPB6

Across TCGA patient cohorts, HSPB6 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPB6-associated genes across cancer lineages are MIR4672, RN7SL592P, and MIR6803. Each is linked with HSPB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPB6-to-partner and partner-to-HSPB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4672 grouped by HSPB6-low versus HSPB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB6→partner) and Y-score (partner→HSPB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4672 →	+0.820	+3.626	<.001	.004	3	1
UCEC	RN7SL592P →	+0.326	+3.538	<.001	.005	3	1
UCEC	MIR6803 →	+0.462	+6.478	<.001	<.001	3	1
UCEC	RNA5SP411 →	+1.370	+3.393	.006	.007	3	1
UCEC	GOLGA8O →	+0.111	+3.834	<.001	.005	3	1
UCEC	RNU6-1024P →	+0.857	+3.837	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MIR4672 by HSPB6 expression — UCEC

Explore this box plot interactively →