HSPB6

Across TCGA pan-cancer cohorts, HSPB6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HSPB6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSPB6 RNA is repressed in tumor relative to normal tissue. In most cancer types HSPB6 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and KICH are the cancer types where HSPB6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPB6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−1.938	<.001	12	view →
BLCA	Male	IV	−8.235	<.001	11	view →
KICH	Male	II,III,IV	−3.661	<.001	11	view →
THCA	Male	IV	−3.330	<.001	11	view →
LUAD	Male	III,IV	−3.223	<.001	11	view →
COAD	Male	All	−3.212	<.001	11	view →
LUSC	Female	All	−3.783	<.001	9	view →
KIRP	All	III,IV	−2.222	<.001	9	view →
HNSC	Male	IV	−4.498	<.001	8	view →
STAD	Female	All	−4.324	<.001	7	view →
READ	All	All	−3.812	<.001	7	view →
UCEC	All	III,IV	−5.417	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HSPB6–KIRC

Open the KIRC breakdown →