HSPB2-C11orf52

Across TCGA pan-cancer cohorts, HSPB2-C11orf52 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated HSPB2-C11orf52 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HSPB2-C11orf52 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HSPB2-C11orf52 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

SKCM, UCS, and KICH are the cancer types where HSPB2-C11orf52 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Quartile	II,III,IV	0.371	0.191	<.001	60	view →
UCS	DFS	Tertile	II,III,IV	0.717	0.291	.002	36	view →
KICH	OS	Tertile	III,IV	0.190	0.803	.007	33	view →
ACC	DFS	Quartile	III,IV	0.042	0.454	<.001	30	view →
KIRP	OS	Median	II,III,IV	0.943	0.700	.002	29	view →
MESO	DFS	Tertile	All	0.702	0.234	.006	24	view →
CHOL	OS	Tertile	All	0.384	0.747	.022	19	view →
KIRC	DFS	Quartile	IV	0.723	0.466	.023	18	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	18	view →
HNSC	DFS	Median	All	0.554	0.711	.005	11	view →
SARC	OS	Tertile	All	0.937	0.675	<.001	8	view →
PAAD	OS	Median	II,III,IV	0.231	0.566	.020	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

HSPB2-C11orf52–SKCM (DFS)

Open the SKCM breakdown →