HSPB2-C11orf52

Across TCGA pan-cancer cohorts, HSPB2-C11orf52 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HSPB2-C11orf52’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where HSPB2-C11orf52 RNA is repressed in tumor relative to normal tissue. In most cancer types HSPB2-C11orf52 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KICH are the cancer types where HSPB2-C11orf52 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPB2-C11orf52 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−0.120	<.001	11	view →
THCA	Female	All	−0.062	<.001	8	view →
KICH	All	All	−0.146	<.001	7	view →
BRCA	All	II,III,IV	−0.189	<.001	6	view →
UCEC	All	All	−0.146	<.001	6	view →
LUSC	Female	II,III,IV	−0.080	<.001	5	view →
COAD	Female	II,III,IV	−0.037	.002	4	view →
HNSC	All	All	−0.058	.015	3	view →
READ	All	All	−0.073	.030	2	view →
LUAD	Female	All	−0.042	<.001	2	view →
PRAD	All	All	−0.032	.001	2	view →
STAD	All	All	−0.024	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HSPB2-C11orf52–BLCA

Open the BLCA breakdown →