HSPB1P1

Across TCGA patient cohorts, HSPB1P1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPB1P1-associated genes across cancer lineages are XKRY2, RNU6-997P, and VN1R3. Each is linked with HSPB1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPB1P1-to-partner and partner-to-HSPB1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XKRY2 grouped by HSPB1P1-low versus HSPB1P1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB1P1→partner) and Y-score (partner→HSPB1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	XKRY2 →	+0.019	+7.954	<.001	.008	3	1
HNSC	RNU6-997P →	+0.262	+7.954	<.001	.008	3	1
UCEC	VN1R3 →	+0.121	+4.567	.001	.001	3	1
UCEC	RNY4P3 →	+0.608	+4.003	<.001	.005	3	1
UCEC	RNU6-13P →	+0.567	+3.969	<.001	.005	3	1
UCEC	RNU1-44P →	+0.482	+4.223	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

XKRY2 by HSPB1P1 expression — HNSC

Explore this box plot interactively →