HSPB1

Across TCGA patient cohorts, HSPB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,801 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HSPB1-associated proteins across cancer lineages are HSPB1_S199, HSPB1_S98, and HSPB1_T143. Each is linked with HSPB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HSPB1-to-partner and partner-to-HSPB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSPB1 versus HSPB1_S199 in LSCC, with a Pearson correlation of 0.83.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB1→partner) and Y-score (partner→HSPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HSPB1_S199 →	+1.446	+1.355	<.001	<.001	3	10
HNSC	HSPB1_S98 →	+0.938	+1.429	<.001	<.001	3	7
HNSC	HSPB1_T143 →	+0.808	+1.426	<.001	<.001	3	7
HNSC	HSPB1_S176 →	+1.268	+1.529	<.001	<.001	3	6
LSCC	HSPB1_S86 →	+0.997	+0.976	<.001	<.001	3	5
LSCC	HSPA13 →	-0.490	-1.100	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,801 associations by consensus.

HSPB1 vs HSPB1_S199 — LSCC

Explore this scatter interactively →