HSPB1

Across TCGA patient cohorts, HSPB1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HSPB1-associated genes across cancer lineages are FXNP1, RPL39P31, and RNU6-535P. Each is linked with HSPB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPB1-to-partner and partner-to-HSPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FXNP1 grouped by HSPB1-low versus HSPB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB1→partner) and Y-score (partner→HSPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FXNP1 →	+0.134	+7.219	<.001	<.001	3	1
SKCM	RPL39P31 →	+0.357	+5.680	<.001	.003	3	1
UCEC	RNU6-535P →	+0.378	+8.066	<.001	.007	3	1
UCEC	RN7SL331P →	+0.188	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FXNP1 by HSPB1 expression — SKCM

Explore this box plot interactively →