HSPB1

Across TCGA cell cohorts, HSPB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,739 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HSPB1-associated GO terms across cancer lineages are Positive regulation of neuromuscular junction development, Anterograde axonal protein transport, and Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Each is linked with HSPB1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HSPB1-to-partner and partner-to-HSPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of neuromuscular junction development grouped by HSPB1-low versus HSPB1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB1→partner) and Y-score (partner→HSPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of neuromuscular junction development →	+0.124	+1.274	<.001	<.001	3	9
URINARY_TRACT	Anterograde axonal protein transport →	+0.193	+1.805	.003	.005	3	9
BLOOD_Lymphoma	Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway →	+0.104	+2.073	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Protein refolding →	+0.150	+3.231	.001	.002	3	8
SOFT_TISSUE	Protein localization to presynapse →	+0.158	+2.203	<.001	<.001	3	8
BLOOD_Lymphoma	Regulation of protein kinase C signaling →	+0.236	+1.908	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,739 associations by consensus.

Positive regulation of neuromuscular junction development by HSPB1 expression — BREAST

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