HSPA8P5

Across TCGA pan-cancer cohorts, HSPA8P5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HSPA8P5 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher HSPA8P5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSPA8P5 expression acts as an unfavorable survival marker, although some lineages such as COAD and READ show a favorable association.

UVM, COAD, and READ are the cancer types where HSPA8P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.421	0.896	.003	80	view →
COAD	DFS	Quartile	All	0.855	0.719	.004	55	view →
READ	DFS	Median	II,III,IV	0.886	0.345	.001	41	view →
ACC	DFS	Tertile	All	0.517	0.918	.005	35	view →
LIHC	DFS	Tertile	All	0.449	0.623	<.001	32	view →
STAD	OS	Tertile	III,IV	0.295	0.677	.003	31	view →
OV	OS	Tertile	IV	0.538	0.273	.015	26	view →
KIRC	OS	Tertile	All	0.720	0.547	.010	15	view →
HNSC	OS	Median	IV	0.506	0.736	.009	15	view →
DLBC	DFS	Median	II,III,IV	0.567	0.971	.016	13	view →
LUSC	OS	Tertile	II,III,IV	0.509	0.361	.016	12	view →
THCA	DFS	Tertile	III,IV	0.935	0.857	.023	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HSPA8P5–UVM (DFS)

Open the UVM breakdown →