HSPA8P4

Across TCGA pan-cancer cohorts, HSPA8P4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HSPA8P4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSPA8P4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPA8P4 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where HSPA8P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPA8P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.184	<.001	11	view →
HNSC	All	All	+0.115	<.001	10	view →
COAD	Male	II,III,IV	+0.150	<.001	9	view →
BRCA	Female	II,III,IV	+0.139	<.001	6	view →
THCA	Female	All	−0.110	<.001	4	view →
READ	All	II,III,IV	+0.250	.020	3	view →
LUAD	All	IV	−0.270	.046	2	view →
LUSC	Male	All	−0.152	<.001	2	view →
PRAD	All	All	+0.051	.029	2	view →
BLCA	All	III,IV	+0.124	.029	1	view →
KIRP	Female	All	+0.093	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HSPA8P4–KIRC

Open the KIRC breakdown →