Across TCGA pan-cancer cohorts, HSPA8P16 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HSPA8P16’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HSPA8P16 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPA8P16 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BRCA, and THCA are the cancer types where HSPA8P16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPA8P16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.038	.013	4	view →
BRCA	All	All	+0.027	.009	4	view →
THCA	Female	All	−0.038	.006	3	view →
READ	Male	All	+0.060	.043	2	view →
PRAD	All	All	+0.037	.012	2	view →
COAD	All	All	+0.050	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: HSPA8P16 RNA expression & survival · all HSPA8P16 data types