HSPA6

Across TCGA pan-cancer cohorts, HSPA6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HSPA6 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HSPA6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSPA6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

UCEC, LUAD, and GBM are the cancer types where HSPA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.929	1.000	.017	10	view →
LUAD	DFS	Tertile	All	1.000	0.823	.031	4	view →
GBM	DFS	Median	All	0.799	0.578	.032	3	view →
PDAC	DFS	Median	III,IV	0.468	0.977	.010	3	view →
HNSC	OS	Quartile	III,IV	1.000	0.270	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HSPA6–UCEC (DFS)

Open the UCEC breakdown →