HSPA6

Across TCGA cell cohorts, HSPA6 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSPA6-associated genes across cancer lineages are OR10C1, TNRC6B, and NISCH. Each is linked with HSPA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA6-to-partner and partner-to-HSPA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10C1 grouped by HSPA6-low versus HSPA6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA6→partner) and Y-score (partner→HSPA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10C1 →	+0.033	+4.266	<.001	.004	3	2
LARGE_INTESTINE	TNRC6B →	+0.938	+3.064	<.001	.009	3	1
LARGE_INTESTINE	NISCH →	+0.737	+3.067	.005	.009	3	1
LARGE_INTESTINE	GALR3 →	+0.085	+3.602	.004	.005	3	1
LARGE_INTESTINE	IPO8 →	+0.658	+3.064	.003	.009	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.382	+2.842	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

OR10C1 by HSPA6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →