Q-omics provides the consensus-scored HSPA5P1 profile across patient tissues and cancer cell-line models. HSPA5P1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, HSPA5P1 is differentially expressed in 13, with the highest sampling consensus in LUSC. Additionally, HSPA5P1 RNA expression shows 16,795 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and LUSC as cancer lineages where HSPA5P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HSPA5P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HSPA5P1 survival associations across molecular data types. HSPA5P1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HSPA5P1 RNA expression–survival associations across cancer types. High HSPA5P1 expression shows unfavorable associations in ACC, UVM, LGG, KIRP, ESCA and LIHC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for HSPA5P1 RNA expression.
This table summarizes HSPA5P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for HSPA5P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HSPA5P1 shows lower tumor expression in THCA and higher tumor expression in LUSC, LIHC, LUAD, COAD and KIRC. The LUSC box plot shows higher HSPA5P1 RNA expression in tumor versus normal tissue (log2 FC = +0.386, t-test p < 0.001).
This table shows molecular features associated with HSPA5P1 in patient tissues and cancer cell lines. In patient samples, HSPA5P1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
