HSPA5

Across TCGA pan-cancer cohorts, HSPA5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HSPA5 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HSPA5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSPA5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where HSPA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.400	0.767	<.001	62	view →
LSCC	OS	Quartile	II,III,IV	0.427	0.853	.004	22	view →
LUAD	OS	Median	II,III,IV	1.000	0.433	.005	20	view →
HNSC	DFS	Tertile	All	1.000	0.269	.016	18	view →
GBM	DFS	Median	All	0.636	0.798	.002	13	view →
PDAC	OS	Tertile	All	0.713	0.977	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HSPA5–CCRCC (DFS)

Open the CCRCC breakdown →