HSPA5

Across TCGA pan-cancer cohorts, HSPA5 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HSPA5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HSPA5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPA5 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where HSPA5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPA5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.088	<.001	12	view →
BLCA	Male	III,IV	+0.957	<.001	11	view →
COAD	All	III,IV	+0.769	<.001	11	view →
THCA	All	IV	−2.394	<.001	10	view →
LUAD	Female	III,IV	+1.283	<.001	9	view →
LIHC	All	II,III,IV	+1.170	<.001	8	view →
STAD	All	III,IV	+1.105	<.001	8	view →
LUSC	All	III,IV	+1.071	<.001	8	view →
KIRC	Female	All	+0.633	<.001	8	view →
BRCA	All	III,IV	+0.788	<.001	6	view →
CHOL	All	All	+1.370	<.001	5	view →
KICH	All	All	−0.842	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HSPA5–HNSC

Open the HNSC breakdown →