HSPA5

Across TCGA patient cohorts, HSPA5 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,846 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HSPA5-associated proteins across cancer lineages are P4HA2, FNDC3B, and PLOD1. Each is linked with HSPA5 in more than 6 cancer types. Because this analysis shows association rather than direction, both HSPA5-to-partner and partner-to-HSPA5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSPA5 versus P4HA2 in GBM, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA5→partner) and Y-score (partner→HSPA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	P4HA2 →	+0.845	+0.423	<.001	<.001	3	7
GBM	FNDC3B →	+0.515	+0.559	<.001	<.001	3	7
GBM	PLOD1 →	+0.742	+0.575	<.001	<.001	3	6
GBM	SIL1 →	+0.390	+0.597	<.001	<.001	3	6
PDAC	NFIA →	-0.386	-0.581	<.001	<.001	3	5
CCRCC	PLOD2 →	+0.933	+0.593	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,846 associations by consensus.

HSPA5 vs P4HA2 — GBM

Explore this scatter interactively →