HSPA5

Across TCGA patient cohorts, HSPA5 protein abundance is significantly associated with the RNA expression of many other genes, with 20,030 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HSPA5-associated genes across cancer lineages are HDAC5, PEBP1, and BAP1. Each is linked with HSPA5 in more than 5 cancer types. Because this analysis shows association rather than direction, both HSPA5-to-partner and partner-to-HSPA5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSPA5 versus HDAC5 in BRCA, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA5→partner) and Y-score (partner→HSPA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HDAC5 →	-0.682	-0.323	<.001	<.001	3	6
HNSC	PEBP1 →	-0.905	-0.189	.004	<.001	3	6
HNSC	BAP1 →	-0.619	-0.199	<.001	.002	3	6
HNSC	FAM219B →	-0.721	-0.235	<.001	<.001	3	6
BRCA	EIF3J-DT →	-0.570	-0.238	<.001	<.001	3	6
COAD	CEP68 →	-0.665	-0.290	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,030 associations by consensus.

HSPA5 vs HDAC5 — BRCA

Explore this scatter interactively →