HSPA5

Across TCGA patient cohorts, HSPA5 mutation is significantly associated with the RNA expression of many other genes, with 2,874 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA5-associated genes across cancer lineages are RNU6-1188P, RN7SKP181, and MIR6853. Each is linked with HSPA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSPA5-to-partner and partner-to-HSPA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1188P grouped by HSPA5-low versus HSPA5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA5→partner) and Y-score (partner→HSPA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1188P →	+0.292	+4.743	<.001	.005	3	3
BLCA	RN7SKP181 →	+0.057	+3.270	.004	.005	3	3
BRCA	MIR6853 →	+0.145	+7.057	<.001	.009	3	2
OV	GIMAP1-GIMAP5 →	+0.019	+6.177	<.001	.001	3	2
LUSC	FAM243A →	+0.035	+5.733	<.001	.001	3	2
UCEC	WFDC2 →	-1.414	-2.048	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,874 associations by consensus.

RNU6-1188P by HSPA5 expression — SKCM

Explore this box plot interactively →