HSPA5

Across TCGA patient cohorts, HSPA5 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA5-associated genes across cancer lineages are eIF4E, Notch1, and XBP1. Each is linked with HSPA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSPA5-to-partner and partner-to-HSPA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HSPA5-low versus HSPA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA5→partner) and Y-score (partner→HSPA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.197	+2.169	.012	.003	3	2
UCEC	Notch1 →	+0.185	+3.713	<.001	<.001	3	2
UCEC	XBP1 →	-0.177	-2.102	<.001	.016	3	2
UCEC	Chk2_pT68 →	-0.166	-2.575	.017	.010	2	3
UCEC	4E-BP1 →	+0.341	+1.904	<.001	.029	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.169	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by HSPA5 expression — UCEC

Explore this box plot interactively →