HSPA5

Across TCGA cell cohorts, HSPA5 mutation is significantly associated with the RNA expression of many other genes, with 168 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSPA5-associated genes across cancer lineages are OXT, PTH, and SLC32A1. Each is linked with HSPA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA5-to-partner and partner-to-HSPA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by HSPA5-low versus HSPA5-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA5→partner) and Y-score (partner→HSPA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OXT →	+0.036	+4.523	.003	.004	3	1
BLOOD_Lymphoma	PTH →	+0.017	+5.247	<.001	.001	3	1
BLOOD_Leukemia	SLC32A1 →	+0.498	+2.486	<.001	.005	3	1
BLOOD_Leukemia	CPZ →	+0.964	+3.438	.002	.004	3	1
BLOOD_Leukemia	CCDC70 →	+0.090	+2.622	<.001	.003	3	1
BLOOD_Leukemia	KIF25 →	+0.361	+3.558	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 168 associations by consensus.

OXT by HSPA5 expression — BLOOD_Lymphoma

Explore this box plot interactively →