HSPA4L

Across TCGA pan-cancer cohorts, HSPA4L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HSPA4L data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSPA4L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HSPA4L expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where HSPA4L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.840	0.475	.003	29	view →
CCRCC	DFS	Tertile	II,III,IV	0.904	0.105	.008	24	view →
LSCC	DFS	Median	All	1.000	0.870	.003	22	view →
UCEC	DFS	Tertile	All	0.948	0.842	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HSPA4L–HNSC (DFS)

Open the HNSC breakdown →