HSPA4L

Across TCGA pan-cancer cohorts, HSPA4L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HSPA4L’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HSPA4L RNA is repressed in tumor relative to normal tissue. In most cancer types HSPA4L is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, LUAD, and LUSC are the cancer types where HSPA4L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPA4L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.881	<.001	9	view →
LUAD	Male	All	+0.855	<.001	9	view →
LUSC	Female	All	+1.585	<.001	7	view →
HNSC	Male	All	+0.652	.008	4	view →
COAD	All	II,III,IV	+0.591	.007	4	view →
BRCA	Female	All	−0.520	<.001	4	view →
KICH	All	All	+0.700	.001	3	view →
ESCA	All	II,III,IV	−2.245	.029	2	view →
READ	All	III,IV	+1.855	.049	2	view →
CHOL	All	All	+1.202	.006	2	view →
PRAD	All	All	−0.834	<.001	2	view →
LIHC	All	All	+0.343	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HSPA4L–THCA

Open the THCA breakdown →