HSPA4L

Across TCGA cell cohorts, HSPA4L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,113 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSPA4L-associated GO terms across cancer lineages are Mitochondrial DNA replication, 'de novo' IMP biosynthetic process, and DNA biosynthetic process. Each is linked with HSPA4L in more than 10 cancer types. Because this analysis shows association rather than direction, both HSPA4L-to-partner and partner-to-HSPA4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial DNA replication grouped by HSPA4L-low versus HSPA4L-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA4L→partner) and Y-score (partner→HSPA4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Mitochondrial DNA replication →	+0.134	+1.668	<.001	<.001	3	11
LUNG_NSCLC_LUSC	'de novo' IMP biosynthetic process →	+0.143	+0.861	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.053	+1.254	.006	.001	3	9
OVARY	Quinone metabolic process →	+0.086	+1.196	.002	.003	3	9
OVARY	AMP metabolic process →	+0.113	+1.223	<.001	.001	3	9
LUNG_NSCLC_LUSC	Ubiquinone metabolic process →	+0.075	+0.801	.007	.003	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,113 associations by consensus.

Mitochondrial DNA replication by HSPA4L expression — SOFT_TISSUE

Explore this box plot interactively →