HSPA4

Across TCGA cell cohorts, HSPA4 mutation is significantly associated with the mutation status of many other genes, with 3,299 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSPA4-associated genes across cancer lineages are FMNL3, ABCA2, and CNGB1. Each is linked with HSPA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both HSPA4-to-partner and partner-to-HSPA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMNL3 grouped by HSPA4-low versus HSPA4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA4→partner) and Y-score (partner→HSPA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FMNL3 →	+3.870	+4.050	.002	.002	1	4
BLOOD_Leukemia	ABCA2 →	+2.115	+3.198	.009	.009	1	4
BLOOD_Leukemia	CNGB1 →	+2.870	+3.347	.009	.009	1	4
BLOOD_Lymphoma	TRPC6 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Leukemia	SLC26A9 →	+3.870	+4.050	.002	.002	1	4
BLOOD_Leukemia	POLR2A →	+3.799	+5.531	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,299 associations by consensus.

FMNL3 by HSPA4 expression — BLOOD_Leukemia

Explore this box plot interactively →