HSPA12A

Across TCGA patient cohorts, HSPA12A mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA12A-associated genes across cancer lineages are Src_pY527, mTOR_pS2448, and TFRC. Each is linked with HSPA12A in more than 3 cancer types. Because this analysis shows association rather than direction, both HSPA12A-to-partner and partner-to-HSPA12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by HSPA12A-low versus HSPA12A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA12A→partner) and Y-score (partner→HSPA12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Src_pY527 →	-0.464	-3.000	.031	.034	3	4
UCEC	mTOR_pS2448 →	-0.140	-1.986	.002	.008	3	4
STAD	TFRC →	+0.578	+2.459	.033	.019	3	3
STAD	4E-BP1_pT37_T46 →	-0.504	-2.459	.002	.019	3	2
STAD	Caspase-7-cleavedD198 →	+0.804	+3.169	.012	.018	2	3
STAD	Caveolin-1 →	-0.809	-2.459	.013	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Src_pY527 by HSPA12A expression — STAD

Explore this box plot interactively →