HSPA12A

Across TCGA pan-cancer cohorts, HSPA12A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HSPA12A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HSPA12A RNA is repressed in tumor relative to normal tissue. In most cancer types HSPA12A is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, HNSC, and THCA are the cancer types where HSPA12A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPA12A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−2.725	<.001	11	view →
HNSC	Female	All	+1.510	<.001	11	view →
THCA	All	III,IV	−1.288	<.001	9	view →
BLCA	Male	IV	−2.350	<.001	8	view →
UCEC	All	II,III,IV	−2.199	<.001	8	view →
KIRC	Male	III,IV	−0.937	<.001	8	view →
KIRP	Male	All	−1.806	<.001	7	view →
BRCA	All	III,IV	−1.265	<.001	6	view →
LIHC	Female	II,III,IV	+1.246	<.001	6	view →
CHOL	Female	All	+2.176	<.001	5	view →
PRAD	All	All	−0.483	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HSPA12A–KICH

Open the KICH breakdown →