HSPA12A

Across TCGA cell cohorts, HSPA12A mutation is significantly associated with the RNA expression of many other genes, with 782 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSPA12A-associated genes across cancer lineages are CCL19, LRIT1, and KRTAP4-7. Each is linked with HSPA12A in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA12A-to-partner and partner-to-HSPA12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL19 grouped by HSPA12A-low versus HSPA12A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA12A→partner) and Y-score (partner→HSPA12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCL19 →	+0.057	+5.415	<.001	.004	3	1
BLOOD_Leukemia	LRIT1 →	+0.026	+3.269	<.001	.007	3	1
BLOOD_Leukemia	KRTAP4-7 →	+0.024	+4.247	<.001	.004	3	1
BLOOD_Leukemia	GIMD1 →	+0.019	+2.982	<.001	.007	3	1
LUNG_NSCLC_LUAD	DDX53 →	+0.801	+3.477	.002	.009	3	1
LUNG_NSCLC_LUAD	TAS2R41 →	+0.059	+3.481	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 782 associations by consensus.

CCL19 by HSPA12A expression — SKIN

Explore this box plot interactively →